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Update on Powassan Virus: Emergence of a North American Tick-Borne g r o . s Flavivirus w e i v e . r y l a l n u o Gregory D. Ebel n n e a s . u s l Department of Pathology, University of New Mexico School of Medicine, Albuquerque, l a a n n New Mexico 87131; email: gebel@ r o u s o r j e r p a r m o o F r . f 0 d 1 e / d 2 a 2 / o 3 l 0 n w n o o D Y . T 0 I 1 S 1- R 5 E 9 : V 5 I 5 N . 0 U 1 0 L 2 L . E l o N m R o O t n C E y v. b Annu. Rev. Entomol. 2010. 55:95–110 Key Words e R u. First published online as a Review in Advance on Deer tick virus, Ixodes, tick-borne encephalitis, encephalitis, zoonosis n August 11, 2009 n A Abstract The Annual Review of Entomology is online at Powassan virus (POW) (Flaviviridae: Flavivirus) is the cause of rare This article’s doi: but severe neuroinvasive disease in North America and Russia. The 10.1146/annurev-ento-112408-085446 virus is transmitted among small- and medium-sized mammals by ixodid c Copyright 2010 by Annual Reviews. ticks. Human infections occur via spillover from the main transmission All