生物信息学电子教案全套课件.pptx

欢迎选修生物信息学;成绩;第三章 生物信息学网络资源(1);National Center for Biotechnology Information (NCBI) ncbi.nlm.nih.gov ;Entrez系统 NCBI综合数据库;Entrez系统的使用方法 ;ncbi.nlm.nih.gov;All Database integrates… the scientific literature; DNA and protein sequence databases; 3D protein structure data; population study data sets; assemblies of complete genomes;All Database is a search and retrieval system that integrates NCBI databases;Accessing information on molecular sequences;Accession numbers（登录号） are labels for sequences;What is an accession number?;Four ways to access DNA and protein sequences;5 ways to access protein and DNA sequences;NCBI’s important RefSeq project: best representative sequences;From the NCBI home page, type “rbp4” and hit “Go”;;;;By applying limits, there are now just two entries;;代码;专业评论;;FASTA format;Entrez Gene (top of page);Entrez Gene (middle of page);Entrez Gene (bottom of page);Example of how to access sequence data: HIV-1 pol;;Searching for HIV-1 pol: Following the “genome” link yields a manageable four results;Example of how to access sequence data: HIV-1 pol;only 1 RefSeq;Four ways to access DNA and protein sequences;;UniGene: unique genes via ESTs;Cluster sizes in UniGene;Cluster sizes in UniGene;Cluster sizes in UniGene (human);UniGene: unique genes via ESTs;练习;Access to Biomedical Literature;PubMed is… National Library of Medicines search service 12 million citations in MEDLINE links to participating online journals PubMed tutorial (via “Education” on side bar);PubMed at NCBI to find literature information;PubMed is the NCBI gateway to MEDLINE. MEDLINE contains bibliographic citations and author abstracts from over 4,600 journals published in the United States and in 70 foreign countries. It has 12 million records dating back to 1966.;;PubMed search strategies;· Journal Database 期刊浏览· MeSh Database 可以用它来分层流览医学主题词· Single Citation Matcher输入期刊的信息可以找到某单篇的文献或整个期刊的内容。· Batch Citution Matcher用一种特定的形式输入期刊的信息一次搜索多篇文献。· Clinical Queries这一部分为临床医生