临床医学临床心血管分子显像.pptxVIP

临床医学临床心血管分子显像第1页/共43页 心血管病国家重点实验室：研究方向心血管疾病的早期预警、诊断和治疗研究分子影像危重心血管疾病创新技术——细胞治疗与生物医学工程研究心血管疾病预测、评估和人群防控第2页/共43页 Gated SPECT第3页/共43页 PET Myocardial Perfusion Imaging第4页/共43页 Cardiac Perfusion and Viability Study by PET/CT75 year old maleScan protocol: low dose CT for attenuation correction PET 740 MBq NH3, 10 minute scan, 370 MBq FDG, 10 minute scanData Courtesy of University of Michigan第5页/共43页 第6页/共43页 PET/CT allows accurate noninvasive clinical decision making about CAD. Because of its high negative predictive value, PET/CT may play an important role in noninvasive selection of CAD patients for revascularization. Integration of higher performance multislice spiral CT scanners into PET/CT hybrids will accelerate the clinical implementation of the PET technique.PET/CT for the diagnosis of CAD第7页/共43页 PET/CT in CADNamdar M, et al. JNM 2005第8页/共43页 Direct Imaging of Exercise-Induced Myocardial IschemiaWith Fluorine-18–Labeled Deoxyglucose andTc-99m-Sestamibi in Coronary Artery DiseaseHe ZX, et al. Circulation 2003第9页/共43页 IschemiaIschemiaand ScarScarNo abnormality16 (31%)6 (12%)*3 (6%)26 (51%)34 (67%)0*017 (33%)p0.001Comparison of abnormalities in Pts with ≥50% narrowing of ≥1 coronary vessels (n=51)99mTc-Sestamibi18FDGHe ZX, Circulation. 2003;108:1208-1213第10页/共43页 Abbott BG, et al. Nucl Med Commun 2007;28:89–94FDG as a memory marker of transient myocardial ischaemia第11页/共43页 71-y-old man (patient 7) with exertional angina, 90% stenosis of LAD and 80% stenosis of LCx and RCADou KF, Yang MF, et al. J Nucl Med 2008 ; 49:1986–1991第12页/共43页 Tl-201 SPECT and FDG PET in HCMIsobe S, et al. J Nucl Med 2003; 44:1717–1724第13页/共43页 Yamano M, Heart 2009;95:1051第14页/共43页 StressRestPersistent chest pain; elevated troponin levels; heart rate 112 bpm, blood pressure 100/50 mmHg; LVEF 30%, biopsy negative for humoral rejectionQuantitative MBF: Rest 0.58 ml/min/g; Stress 0.86 ml/min/g; MBF Reserve = 1.4616 year old female, 2 years after heart transplantMicrovascular Dise