血清25羟维生素D_3水平与2型糖尿病下肢血管病变的关系研究.docVIP

GIP Chinese General Practice 2011年10月第14卷第108期 ·3331 · · 论 著 · 血清25 羟维生素 D? 水平与2型糖尿病下肢血管病变 的关系研究 陈雄，陈恩德，龚小花，谷雪梅，郑景晨，沈飞霞 【摘要】 目的 探讨血清25羟维生素D,[25(OH)D?] 水平与2型糖尿病患者下肢血管病变 (LLPAD) 的 关系。方法 选取210例2型糖尿病患者 (T2DM 组),根据下肢血管超声结果将患者分为LLPAD 组(94例)和无下 肢血管病变 (Non-LLPAD) 组(116例),并选取同期来本院体检的50例健康者为对照组。对每位患者进行临床资料 收集及常规生化指标检测，采用电化学发光法检测所有受试者血清25 (OH)D? 水平。结果 LLPAD 组患者血清25 (OH)D, 水平显著降低，与 Non-LIPAD 组比较差异有统计学意义 (P0.05)。 多因素 Logistic 回归分析发现年龄 (OR=1.064,P=0.001)、 吸 烟 (OR=3.639,P=0.001)、 舒张压 (OR=1.046,P=0.010)、 糖化血红蛋白 (HbA,e)(OR=1.188,P=0.048)、 低密度脂蛋白胆固醇 (LDL-C) (OR=1.520,P=0.028)、25(OH)D? (OR =0.096,P=0.001) 是糖尿病下肢病变的独立危险因素。结论 低维生素 D 水平、高龄、吸烟、高HbA,e、 高舒张 压、高LDL-C 与2型糖尿病患者LLPAD 的发生密切相关。 【关键词】 糖尿病，2型；下肢血管病变；动脉粥样硬化；维生素 D; 骨化二醇 【中图分类号】 R587.23 【文献标识码】 A 【文章编号】1007-9572(2011)10-3331-04 Relationship between Serum 25 - Hydroxyvitamin D, Concentrations and Lower Limb Peripheral Arterial Dise ase in Type 2 Diabetic Patients CHEN Xiong,CHEN En -de,GONG Xiao -hua, et al. Department of Endocrinology, the First Affiliated Hospial of Wenzhou Medical College,Wenzhou 325000,China 【Abstract] Objective To explore the relationship between 25 -hydroxyvitamin D,[25(OH)D?,VD] and lower limb peripheral arterial disease(LLPAD).Methods A total of 210 type 2 diabetic patients and 50 non - diabetic healthy sub- jects were enrolled in this study. All the diabetic patients underwent ultrasonography and were divided into 2 groups [LLPAD group(n=94)and non-LLPAD group(n=116)].Clinical data were collected, routine biochemical indices were deter- mined,and serum VD were measured in the diabetic patients and the non - diabetic healthy subjects. Results VD levels de- creased significantly in the LLPAD group, with statistically significant differences from the non -LLPAD group(P0.05). Multivariate logistic regression revealed that age(OR=1.064,P=0.001),smoking(OR=3.639,P=0.001),DBP(OR