瑞舒伐他汀钙联合缬沙坦治疗早期糖尿病肾病疗效观察.docVIP

·3787 · · 专 题 研 究 · 瑞舒伐他汀钙联合缬沙坦治疗早期糖尿病肾病疗效观察 王晓东，李红涛，包春艳，马波，兰丽娟，吴书元，杨涛 【摘要】 目的 探讨瑞舒伐他汀钙联合缬沙坦对早期糖尿病肾病 (DN) 的保护作用。方法 将97例早期 DN 患者随机分为对照组、缬沙坦单药治疗组(单药治疗组)、瑞舒伐他汀钙与缬沙坦联合治疗组(联合治疗组)。3组患 者均行常规降糖治疗，单药治疗组在常规降糖治疗基础上加用须沙坦80mg/d, 联合治疗组在常规降糖治疗基础上加用 缬沙坦80 mg/d 和瑞舒伐他汀钙片10mg/d。 疗程均为12周。检测并比较治疗前后3组患者血糖[空腹血糖 (FBG)、 餐后血糖 (PBG)]、 血脂[总胆固醇 (TC)、 三酰甘油 (TG)、 高密度脂蛋白胆固醇 (HDL-C)、 低密度脂蛋白胆固 醇 (LDL-C)]、 糖化血红蛋白 (HbA。)、 血肌酐 (SCr) 及24h 尿微量清蛋白排泄率 (UAER) 等指标的变化。结果 治疗后，联合治疗组患者血脂 [TC、TG、LDL-C]、 血糖 (FBG、PBG)、HbA,。、UAER 均较治疗前显著降低，差 异有统计学意义 (P0.05); 且治疗后联合治疗组与单药治疗组比较，血脂、 UAER 也显著降低，差异有统计学意义 (P0.05);3 组患者SCr水平无论在治疗前还是治疗后，差异均无统计学意义 (P0.05)。 结论 瑞舒伐他汀钙与 缬沙坦联合治疗早期 DN, 不仅能降低血脂和血压，还能减少患者的UAER, 可有效预防和延缓早期糖尿病肾损害的进 展。 【关键词】 糖尿病肾病；瑞舒伐他汀钙；缬沙坦；治疗结果 【中图分类号】 R587.24 【文献标识码】 A 【文章编号】1674-3296(2011)11-3787-03 Evaluation of the Therapeutic Effects of Rosuvastatin Combined with Valsartan in Treating Early Diabetic Nephropathy WANG Xiao-dong,LI Hong-tao, BA0 Chun -yan, et al. Hospital of Tiarjin Armed Police Forces,Tianjin 300162,China 【Abstract】 Objective To observe the clinical efficacy of Rosuvastatin combined with Valsartan in early diabetic ne- phropathy. Methods A total of 97 patients of early diabetic nephropathy were randomly divided into 3 groups(the Valsartan ther- apy group, the Rosuvastatin and Valsartan combined group and the control group). All the three groups received routine treat- ment, the Valsartan therapy group received additional oral valsartan(80 mg/d),and the combined group received additional o- ral Rosuvastatin(10 mg/d) combined with valsartan(80 mg/d),all for 12 weeks. Blood glucose, HbA 。, serum lipids(TC, TG, HDL-C and LDL-C),SCr,and 24 h urinary albumin excretion(UAER)were measured and compared among the three groups before and after 12 weeks of treatment. Results After treatment, blood glucose(fasting glucose and postprandial glu- cose),HbA,e,serum lipids(TC, TG and LDL-C),and UAER were significantly reduced in the combined therapy group than in the other two groups(P0.05).Co