新诊断2型糖尿病两种胰岛素治疗模式的临床效果研究.docVIP

GIP Chinese General Practice 2010年4月第13卷第4C期 · 1285 · · 论 著 · 新诊断2型糖尿病两种胰岛素治疗模式的临床效果研究 陈彬，吕肖锋，焦秀敏，王雅杰 【摘要】 目的 探讨短期胰岛素泵持续皮下输注 (CSII) 与预混人胰岛素30R 常规2次皮下注射对新诊断2型 糖尿病患者的疗效差异。方法 将110例新诊断2型糖尿病患者随机分为两组，其中CSII组采用CSⅡI诺和灵 R 治疗； 常规2次皮下注射组于早、晚餐前30 min皮下注射预混人胰岛素30R 治疗，比较治疗后两组血糖达到良好控制所需时 间及治疗2周后新诊断2型糖尿病患者的缓解率。 结果 CSII组和常规2次皮下注射组患者治疗后均可有效降低血糖， CSII组血糖达到良好控制时间明显快于常规2次皮下注射组，两组比较差异有统计学意义 (P0.01)。 治疗2周后， 停用胰岛素1周，仅使用饮食控制及运动疗法，2型糖尿病患者病情缓解率CSII组明显高于常规2次皮下注射组，两 组比较差异有统计学意义 (P0.05)。 结论 新诊断2型糖尿病患者短期应用CSII胰岛素模式，使血糖达到良好控制 的时间短于应用预混人胰岛素30R 常规2次皮下注射模式，且2型糖尿病患者病情的缓解率也较高。 【关键词】 糖尿病，2型；胰岛素泵；注射，皮下 【中图分类号】 R587.1 【文献标识码】 A 【文章编号】1007-9572(2010)04-1285-02 C linical Effect of Two Insulin Treatment Methods for Newly Diagnosed 2 Diabetic Mellitus CHEN Bin, LV Xiao -feng, JIAO Xiu-min,et al. Department of Endocrinology, General Hospital of Beijing Military Region,Beijing 100700,China 【Abstract] Objective To discuss the clinical effect of continuous subcutaneous insulin infusion(CSII) or Novolin 30R on newly diagnosed type 2 diabetic mellitus(T2DM). Methods One hundred ten T2DM patients were randomly divided into groups CSII(receiving CSII novolin R)and Convention(receiving subcutaneous injection of premixed human insulin-30R, 30 min before breakfast,dinner). The required time that good blood glucose(BG) control was achieved and the remission rate of newly - diagnosed T2DM patients after 2 weeks of treatment were compared between 2 groups. Results Blood glucose were re- duced effectively after treatment, the required time that good BG control was achieved was shorter in CSlI group than in conven- tion group, the difference was significant(P0.01). After 2 weeks of treatment, insulin was stopped for 1 week, using only diet control and exercise therapy, the remission rate of CSII group was significantly higher than that of convention group(P 0.05). Conclusion Short -term application of CSII insulin in newly -diagnosed T2DM patients need shorter required time that good BG control is