彩色多普勒超声对儿童糖尿病肾动脉血流动力学变化的研究.docVIP

腹部影像学 Abdominal Imaging中国医学影像学杂志 Chinese Journal of Medical Imaging 腹部影像学 Abdominal Imaging ,;Dopplersse)rs;Hemodynamics; , ; Doppler s s e ) r s ; Hemodynamics; nephropathies; 论著 Original 论著 Original Research 彩色多普勒超声对儿童糖尿病肾动脉血流动力学变化的研究 Hemodynamic Changes of Renal Artery in Diabetic Children with Color Doppler UItrasonography 贺雪华HE Xuehua 关步云GUAN Buyun 朱莉玲ZHU Liling 方 倩FANG Qian 【摘要】目的 通过研究1型糖尿病儿童肾叶间动脉血流动力学指标参数的变化 探讨彩色多普勒超声检查对糖尿病肾病潜伏期的临床应用价值。 资料与方法 选取 1型糖尿病儿童52例及健康对照组51例进行肾脏彩色多普勒超声检查，测量肾叶 间动脉的阻力指数 (RI), 并对其临床资料及实验室指标进行比较。 结果 糖尿病组 左肾RI、右肾RI及双肾平均RI均较对照组明显增高，差异有统计学意义 (P0.01)。 糖尿病组平均RI与糖化血红蛋白呈正相关 (r=0.96,P0.01), 与糖尿病持续时间 亦呈正相关 (r=0.31,P0.01)。糖尿病组空腹血糖、糖化血红蛋白、肾小球滤过率 均明显高于对照组，差异有统计学意义 (P0.01)。结论 1型糖尿病患儿肾叶间动 脉RI指数增高，彩色多普勒超声检查能提示肾脏血流动力学改变情况，对早期糖 尿病肾病诊断具有 定的价值。 【关键词】 糖尿病，1型；超声检查，多普勒，彩色；肾动脉；血流动力学；糖尿病肾病 儿 童 【Abstract】Purpose To study the hemodynamic changes of kidney interlobar artery in children with type 1 diabetes, and to explore the clinical value of the color ultrasound in diabetic nephropathy during the incubation period. Materials and Method The study was performed in 52 children with type 1 diabetes and in 51 age-matched healthy children as control group. The resistance index (RI) of interlobar artery wa measured with color Doppler ultrasonography, and the clinical data and laboratory indicators were analyzed. Results The left kidney RI, right kidney RI and averag RI were all significantly higher in children with diabetes than in age-matched healthy group (P0.01). The mean RI were correlated positively with (HbA; 。)(r=0.96,P0.01 and diabetes duration (r=0.31,P0.01), respectively. Fasting blood glucose, glycated hemoglobin, and glomerular filtration rate were significantly higher in children with diabetes than in age-matched healthy group (P0.01). Conclusion The RI of interloba artery increases in children with type I diabetes. Early changes of renal hemodynamic in children with type 1 diabetes are detectable with Doppler sonography, and have c