达托霉素课件.ppt

参考文献 [1]Hawkey P M. Pre-clinical experience with daptomycin. Journal of Antimicrobial Chemotherapy, 2008, 62(Suppl 3): iii7–iii14. [2] Baddour LM, Wilson WR, Bayer AS, et al. Infective Endocarditis in Adults: Diagnosis, Antimicrobial Therapy, and Management of Complications: A Scientific Statement for Healthcare Professionals From the American Heart Association. Circulation. 2015, 132(15):1435-86 [3] Habib G, Lancellotti P, Antunes MJ, et al. 2015 ESC Guidelines for the management of infective endocarditis. European Heart Journal, 2015 [4] Gould FK, Denning DW, Elliott TS, et al. Guidelines for the diagnosis and antibiotic treatment of endocarditis in adults: a report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother 2012; 67: 269–289 [5] 中华医学会心血管病学分会,中华心血管病杂志编委会. 成人感染性心内膜炎预防、诊断和治疗专家共识. 中华心血管病杂志, 2014, 42(10):806-816 [6] Dare, R.K., et al., Statin Coadministration Increases the Risk of Daptomycin-Associated Myopathy. Clin Infect Dis. [7] Saito et al. Dose?dependent artificial prolongation of prothrombin time by interaction between daptomycin and test reagents in patients receiving warfarin: a prospective in vivo clinical study. Ann Clin Microbiol Antimicrob, 2017, 16:27 [8] Gilchrist MJ, Moore LSP, Thomas CP, et al. Daptomycin and warfarin--an important clinical observation. The British Journal of Clinical Pharmacy, 2013 [9] Smith SE, Rumbaugh KA . False prolongation of International Normalized Ratio associated with daptomycin. Am J Health-Syst Pharm. 2018, 75:269-74 [10] Soon, R.L., et al., Pharmacokinetic/pharmacodynamic evaluation of the efficacy and safety of daptomycin against Staphylococcus aureus. Int J Antimicrob Agents, 2013. 42(1): p. 53-8. r2=0.57, p0.001 r2=0.56, p0.001 Saito et al. Ann Clin Microbiol Antimicrob, (2017) 16:27 结论 高浓度的DAP通过与PT试剂相互作用可导致PT-INR的假性升高，且升高幅度可能为临床不可忽视的，特别是服用华法林患者接受高剂量DAP，建议最好是在DAP谷浓度而非峰浓度时测定PT。 Q5 服用华法林的患者接受DAP治疗时INR超过治疗范围，华法林停or不停？ 44y，男，1997 年因感染性心内膜炎行 主动脉瓣置换术（生物瓣），主