先天性甲状腺功能减退（英文版）.pptVIP

Congenital Hypothyroidism Here comes your footer ? Page 2Definition and CategoryPhysiology and PathologyEtiologyClinical ManifestationsLaboratory FindingsDifferential DiagnosisTreatmentFollow UpPrognosis Here comes your footer ? Page 3DefinitionCongenital hypothyroidism (CHT) is a condition of thyroid hormone deficiency present at birth. If untreated for several months after birth, severe CH can lead to growth failure and permanent mental retardation. Here comes your footer ? Page 4定义先天性甲状腺功能减低症（Congenital hypothyroidism,CH)简称先天性甲低， 是因甲状腺激素产生不足或其受体缺陷所致的先天性疾病。 如果生后未及时治疗，将导致生长迟缓和智力低下。 Here comes your footer ? Page 5Congenital Hypothyroidism ——Primary hypothyroidism, in which the thyroid doesnt produce an adequate amount of T4. ——Secondary hypothyroidism develops when the pituitary gland does not release enough of the thyroid-stimulating hormone (TSH) that prompts the thyroid to manufacture T4 Category Here comes your footer ? Page 6Congenital HypothyroidismCH is also classified into permanent and transientPermanent CH refers to a persistent deficiency of thyroid hormone that requires life-long treatmentTransient CH refers to a temporary deficency of thyroid hormone,discovered at birth,but then recovering to normal in the first few months or years of lifeThe incidence rate of CH is 1/3000~1/5000.Category Here comes your footer ? Page 7Congenital HypothyroidismSynthesis of Thyroid Hormonethyroid hormone triiodothyronine (T3) thyroxine (T4)Materials iodine, tyrosineSteps1. Iodine trapping2. Iodine oxidized3. Tyrosine iodinate4. Iodotyrosine condensationPhysiology and Pathology Here comes your footer ? Page 8Congenital HypothyroidismRegulation of Thyroid FunctionPhysiology and Pathology Here comes your footer ? Page 9regulaton of H-P-TTRH synthesized in the hypothalamus are secreted into the hypophysial portal circulationTSH are then secreted by the pituitary gland(hypophysis) in response, and in turn act on thyroid gland to stimulate the secreti