国际单克隆抗体研究文献分析.pdfVIP

国际单克隆抗体研究文献分析

通过比较分析1999-2008年单克隆抗体主要研究国家和机构的科研产出及单克隆抗体的研

究领域、热点等，为科研工作者和科研管理者提供参考。方法利用文献计量学方法，对

WebofScience(SCIE)收录的单克隆抗体论文的时间、国家、机构、期刊进行分析；同时结

合共词分析、聚类分析和可视化分析方法，对单克隆抗体研究有关的论文开展主题分析。结

果SCIE收录单克隆研究文献50357篇，美国在文献数量和质量上遥遥领先，中国与美国等

发达国家差距较大；单克隆抗体研究属多学科交叉领域，CD40分子、EGFR等是当前研究

的热点。结论中国应加大单克隆抗体资金投入,加强与顶级科研院所的交流合作，紧跟研究

热点，提高自主创新能力。

AnalysisofMonoclonalAntibodyResearchLiteraturesintheWorld

LIHai-cun,WANGMin,XUPei-yang

Instituteofmedicalinformation,PekingUnionmedicalcollege,Beijing100020,China

AbstractObjectiveTocomparetheoutputsonmonoclonalantibodyresearchofthemajorresearch

instituteandcountriesinwhichtheresearchwereconductedfrom1999to2008andfindthemajor

researchfieldandhottopics,providereferenceforthemonoclonalantibodyresearchandthe

managementinChina.MethodsThepapersonmonoclonalantibodyweresearchedinwebof

sciencedatabase(SCIE),andbyusingbibliometricmethod,thepublishingyears,theauthors

countries/institutesandthepublishingjournalsofthepaperswereanalyzed;Themainsubjects

andtopicswereanalyzedbyusingco-wordanalysis,clusteranalysisandvisualizationanalysis.

ResultsAtotalof50357papersweresearchedinSCIE,thepapersfromUSAwereinthelargest

quantityandwiththebestquality.ThemonoclonalantibodyresearchinChinawaslagging

comparedwiththedevelopedcountries.Monoclonalantibodyresearchisamultidisciplinaryfield

andwiththehottopicsofCD40molecule,EGFRandothersatpresent.ConclusionItisnecessary

toincreasetheinvestmentonmonoclonalantibodyresearchinChina,strengthenthecooperation

betweenscientificresearchinstitutesandconductresearchesonhottopicstomaketheinitiatives

onmonoclonalantibodyresearch.

KeywordsMonoclonalantibody;Informationvisualization;Bibliometrics;Clusteranalysis;

Co-wordanalysis

《国家中长期科学