Monatepil-maleate-AJ-2615-DataSheet-生命科学试剂-MCE.pdf

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Monatepilmaleate

Cat.No.:HY-106818A

CASNo.:103379-03-9

Synonyms:AJ-2615

分⼦式:C₃₂H₃₄FN₃O₅S

分⼦量:591.69

作⽤靶点:Acyltransferase;CalciumChannel

作⽤通路:MetabolicEnzyme/Protease;MembraneTransporter/Ion

Channel;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Monatepilmaleate(AJ-2615)是⼀种有效的具有⼝服活性的Ca2+-通道拮抗剂和⾮竞争性ACAT抑制剂。

Monatepilmaleate可降低⾎压并改善⾎浆脂质代谢。Monatepilmaleate具有研究⾼脂⾎症的潜⼒[1][2]。

体内研究Monatepilmaleate(30mg/kg;p.o.;oncedailyfor9weeks)improvesplasmalipidmetabolism[1].

Monatepilmaleate(30mg/kg;p.o.;oncedailyfor6weeks)inhibitsACATactivityandesterifiescholesterol

contentinhighcholesteroldietmonkeys[2].

AnimalModel:8weeks,Malejapanesewhiterabbits(highcholesteroldiet-fed)[1]

Dosage:30mg/kg

Administration:P.o.;oncedailyfor9weeks

Result:Improvedplasmalipidmetabolismandreducedatheroscleroticlesions,decreasedblood

pressure.

AnimalModel:4-7kg,4-7yearsmonkeys(highcholesteroldietfo