(2.4)--基于计算的药物设计Analysis of therapeutic生物信息学.pdf

(2.4)--基于计算的药物设计Analysis of therapeutic生物信息学.pdf

此“医疗卫生”领域文档为创作者个人分享资料,不作为权威性指导和指引,仅供参考
  1. 1、本文档共44页,可阅读全部内容。
  2. 2、原创力文档(book118)网站文档一经付费(服务费),不意味着购买了该文档的版权,仅供个人/单位学习、研究之用,不得用于商业用途,未经授权,严禁复制、发行、汇编、翻译或者网络传播等,侵权必究。
  3. 3、本站所有内容均由合作方或网友上传,本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺!文档内容仅供研究参考,付费前请自行鉴别。如您付费,意味着您自己接受本站规则且自行承担风险,本站不退款、不进行额外附加服务;查看《如何避免下载的几个坑》。如果您已付费下载过本站文档,您可以点击 这里二次下载
  4. 4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等,请点击“版权申诉”(推荐),也可以打举报电话:400-050-0827(电话支持时间:9:00-18:30)。
查看更多

JournalPre-proof

AnalysisoftherapeutictargetsforSARS-CoV-2anddiscoveryofpotentialdrugsby

computationalmethods

CanrongWu,YangLiu,YueyingYang,PengZhang,WuZhong,YaliWang,Qiqi

Wang,YangXu,MingxueLi,XingzhouLi,MengzhuZheng,LixiaChen,HuaLi

PII:S2211-3835(20)30299-9

DOI:/10.1016/j.apsb.2020.02.008

Reference:APSB788

Toappearin:ActaPharmaceuticaSinicaB

ReceivedDate:12February2020

RevisedDate:17February2020

AcceptedDate:18February2020

Pleasecitethisarticleas:WuC,LiuY,YangY,ZhangP,ZhongW,WangY,WangQ,XuY,LiM,LiX,

ZhengM,ChenL,LiH,AnalysisoftherapeutictargetsforSARS-CoV-2anddiscoveryofpotentialdrugs

bycomputationalmethods,ActaPharmaceuticaSinicaB,/10.1016/j.apsb.2020.02.008.

ThisisaPDFfileofanarticlethathasundergoneenhancementsafteracceptance,suchastheaddition

ofacoverpageandmetadata,andformattingforreadability,butitisnotyetthedefinitiveversionof

record.Thisversionwillundergoadditionalcopyediting,typesettingandreviewbeforeitispublished

initsfinalform,butweareprovidingthisversiontogiveearlyvisibilityofthearticle.Pleasenotethat,

duringtheproductionprocess,errorsmaybediscoveredwhichcouldaffectthecontent,andalllegal

disclaimersthatapplytothejournalpertain.

©2020ChinesePharmaceuticalAssociationandInstituteofMateriaMedica,ChineseAcademyof

MedicalSciences.ProductionandhostingbyElsevierB.V.Allrightsreserved.

Graphicalabstract

Twentystructuresincluding19SARS-CoV-2targetsand1humantargetwerebuiltbyhomology

modeling.LibraryofZINCdrugdatabase,naturalproducts,78anti-viraldrugswerescreened

againstthesetargetsplushumanACE2.Thisstudyprovidesdrugrepositioningcandidatesand

targetsforfurtherinvitroandinvivostudiesof

您可能关注的文档

文档评论(0)

177****2883 + 关注
实名认证
内容提供者

热爱教育,专注于教育领域创作与分享,让我们共同进步。

1亿VIP精品文档

相关文档