rhbFGF、rhIGF-I与人工骨复合促进犬牙周组织再生的实验研究的开题报告.docxVIP

rhbFGF、rhIGF-I与人工骨复合促进犬牙周组织再生的实验研究的开题报告

【摘要】

目的：探究rhbFGF（人重组碱性成纤维细胞生长因子）、rhIGF-I（人重组胰岛素样生长因子I）与人工骨复合在促进犬牙周组织再生方面的作用机制，为进一步优化临床牙周病的治疗方法提供实验依据。

方法：选取健康的成年狗8只，进行牙周病模型制备，采用人工骨、rhbFGF和rhIGF-I的联合应用方法，随机分为实验组和对照组，观察治疗前后的狗咬颌度、牙周袋深度、牙周炎指数及组织学变化，比较两组之间的差异。

预期结果：实验组的治疗效果将明显优于对照组，表现为狗咬颌度的明显提高、牙周袋深度的显著减少、牙周炎指数的明显降低、组织学方面石膏基质的吸收速度加快，新骨生长明显增加。

结论：rhbFGF、rhIGF-I与人工骨复合可显著促进犬牙周组织再生，是有望作为临床牙周病治疗新方法的重要组成部分。

【关键词】牙周炎；rhbFGF；rhIGF-I；人工骨；再生

【Abstract】

Objective:ToexplorethemechanismofrhbFGF(recombinanthumanbasicfibroblastgrowthfactor),rhIGF-I(recombinanthumaninsulin-likegrowthfactorI)andartificialbonecompositeinpromotingperiodontaltissueregenerationindogs,andtoprovideexperimentalevidenceforfurtheroptimizingthetreatmentmethodsofclinicalperiodontaldisease.

Methods:Eighthealthyadultdogswereselectedandperiodontaldiseasemodelswereprepared.Thecombinedapplicationofartificialbone,rhbFGFandrhIGF-Iwasused,andtheywererandomlydividedintoexperimentalgroupandcontrolgroup.Thedifferencesbetweenthetwogroupswerecomparedbyobservingthebitedegree,periodontalpocketdepth,periodontalindexandhistologicalchangesbeforeandaftertreatment.

Expectedresults:Thetreatmenteffectoftheexperimentalgroupwillbesignificantlybetterthanthatofthecontrolgroup,manifestedasasignificantincreaseinthebitedegreeofdogs,asignificantdecreaseinperiodontalpocketdepth,asignificantreductioninperiodontalindex,anacceleratedabsorptionrateofgypsummatrixintissuehistology,andasignificantincreaseinnewbonegrowth.

Conclusion:ThecompositeofrhbFGF,rhIGF-Iandartificialbonecansignificantlypromoteperiodontaltissueregenerationindogs,andisexpectedtobecomeanimportantpartofnewclinicaltreatmentmethodsforperiodontaldisease.

【Keywords】Periodontitis;rhbFGF;rhIGF-I;Artificialbone;Regeneration