帕金森病患者手指静止性震颤的量化评估 .pdf

帕金森病患者手指静止性震颤的量化评估

汪加胜;项尚;徐大兵;刘遥;王佳炜;程楠;王训

【摘要】目的量化评估帕金森病(PD)患者手指静止性震颤程度,以及寻找PD与帕

金森综合征(PS)患者鉴别诊断的客观量化指标.方法选取29例PD患者、28例PS

患者[其中包括16例多系统萎缩P型(MSA-P)患者和12例血管性帕金森综合征

(VP)患者]和39例正常老年人,运用基于传感器技术的手指静止性震颤量化评估系

统,采集静止状态下各组受试者的拇指、食指的加速度、角速度,计算拇指、食指的

静止性震颤的频率及其震颤波曲线相似熵(ApEn).结果与正常对照组、MSA-P及

VP患者比较,PD患者拇指、食指的静止性震颤的频率增高(P＜0.05),ApEn数值偏

低(P＜0.05);与正常对照组比较,MSA-P患者拇指、食指的静止性震颤的频率增高

(P＜0.01),拇指ApEn数值偏低(P＜0.05),食指ApEn差异无统计学意义;与正常对

照组比较,VP患者拇指、食指的静止性震颤的频率及ApEn差异无统计学意义.结

论拇指、食指的静止性震颤的频率及其Ap-En等指标能客观量化评估PD患者手

指静止性震颤程度,且可作为PD与PS患者鉴别诊断的客观量化指标.%Objective

Toassessquantitativelythedegreeoffingerrestingtremorinpatients

withParkinsonsdisease(PD),andtofindtheobjectivequantitative

indicatorsforthedifferentialdiagnosisofpatientswithPDandParkinsons

syndrome(PS).Methods29patientswithParkinsonsdisease(PD),28

patientswithParkinsonssyndrome(PS)[including16casesofmultiple

systematrophy-parkinsonian(MSA-P)patientsand12casesofvascular

parkinsonism(VP)],and39casesofnormalagingwereselected,basedon

thesensingtechnologyquantitativeassessmentsystemoffingerrest-

tremor,collectedaccelerationandvelocityofthumbandforefingerunder

stationarystate,thencalculatethefrequencyofthethumbandindexfinger

resttremorandAchieveapproximateentropy(ApEn).ResultsThenormal

controlgroupwascomparedwiththeMSA-PandVPpatients,PDpatients

withincreasedfrequencyofthethumb,indexfingerresttremor(P＜

0.05),thenumericalofApEnlower(P＜0.05);Comparedwithnormal

controlgroup,patientswithMSA-Pincreasedthefrequencyofthe

thumb,indexofstatictremor(P＜0.01),thethumbApEnvalueislower(P＜

0.05),theindexfingerApEnhadnostatisticalsignificance;Comparedwith

normalcontrolgroup,thefrequencyandApEnofthumbandindexfinger

resttremorofVPpatientshadnostatisticalsignificance.ConclusionThe

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