分子医学-表观遗传学.pptVIP

Epigenetics

ClassicalGenetics:TheCentralDogmaIntroductiontoEpigenetics

TheHumanGenomeProject(HGP)Keyfindings:approx.24,000genesinhumanbeingallhumanracesare99.99%alikeChallenges:about24,000genesvs.100,000proteinsnon-coding(98%)vs.codingDNA(2%)genotypevs.phenotypeIntroductiontoEpigenetics

Theymaylookthesame,butarethey?Position-effectvariegationParamutationatthemaizeEpigeneticbiologyIntroductiontoEpigenetics

Epigeneticdifferencesariseduringthelifetimeofmonozygotictwins5mCAcH4AcH3PNAS,July26,2005,Vol.102IntroductiontoEpigenetics

Epige