feizhen wu ibs表观遗传学实验室1systembiology.pptx

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feizhen wu ibs表观遗传学实验室1systembiology.pptx

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FeizhenWuEpigeneticslabatIBS1Genome,EpigenomeandHigh-throughputSequencing

1.Genome,Genomics,and-omics2.HumanGenomeEncyclopedias3.Epigenomeandepigenetics4.Genomevisualization5.GenomeSequencing-SolexaOutline2

3Genome,Genomics,

and-omics

Genomeisthecompletesetofgenesofanorganism.Other–omicsincludefunctionalgenomics,transcriptomics,proteomics,metabolomics,phenomics(-omics).Genomicsisthestudyofallgenespresentinanorganism,includingsequencing,mapping,andcharacterizinggenomes.4

Eachandeveryoneisauniquecreation;Humanbodyhas1013cellsandeachcellhasabout3billionbasepairs(A,C,G,T);Thegenomedetermineswhichandwhenproteinshouldbemade;Thecompositionofgenomeiscommontoallorganisms.5Whydowestudygenomes?

Biotechnology:moreproductsGMO(GeneticallyModifiedOrganisms):Morefood-Moreproblems?IndividualizedmedicineGenetherapyDiseasefreelife?……6Significancesingenomicsstudy

7Someonehasacancergene!Itisanormalgenethatgotmutatedorchangedanddoesnotperformsamejob.Buthavingagenedoesnotmeanyouwillgetcancer.Becauseenvironmenthasabigroleinturningageneonoroff(epigenome).Differentgenesandtheirproductsalsointeract:microecosystem.

8Howtostudygenome?Combinationofmolecularbiologyandcomputerscience.ToolsandtechniquesofbinantDNAtechnologye.g.,DNAsequencing,makinglibrariesandPCRsHigh-throughputtechnologye.g.,roboticsforsequencingComputersareessentialforprocessingandanalyzingthelargequantitiesofdatagenerated

9HumanGenome

HumanGenomeProjectGoals:?■identifyalltheapproximate30,000genesinhumanDNA,■determinethesequencesofthe3billionbasepairsthatmakeuphumanDNA,■storethisinformationindatabases,improvetoolsfordataanalysis,■transferrelatedtechnologiestotheprivatesector,and■addresstheethical,legal,andsocialissues(ELSI)thatmayarisefromtheproject.?Milestones:■19