川崎病凝血功能检测动态观察的临床意义探讨.pdfVIP

川崎病凝血功能检测动态观察的临床意义探讨

【摘要】目的探讨川崎病患儿不同时期凝血功能与疾病进展的关系,为指

导临床诊治、减少后天性心血管疾病提供科学依据。方法监测KD组和对照组

患儿不同时期凝血功能及与冠状动脉病变发生的关系。结果①KD组患儿D-二

聚体升高者极显著高于对照组(P＜0.01);②动态观察KD组与对照组D-二聚体升

高比较＜7d组、7~14d组差异均极显著(P＜0.01),＞14d组无差异(P＞0.05);③

CAD组与NCAD组D-二聚体升高比较无差异(P＞0.05);④动态观察CAD组与

NCAD组D-二聚体升高比较＜7d组无差异(P＞0.05),7~14d组差异极显著(P＜

0.01),＞14d组有显著差异(P＜0.05)。结论D-二聚体可作为KD早期诊断的重要

指标之一,动态观察D-二聚体具有预测冠状动脉损伤的价值。

【Abstract】ObjectiveToresearchtherelationbetweentheprogressofdisease

withcoagulationfunctionindifferentphasesofkawasakidisease(KD)toprovide

foundationforguidethediagnosisandtreatmentandreducetheincidenceofacquired

cardiovasculardisease.MethodsMonitortherelationofprogressofdiseasewith

coronaryarterydisease(CAD)indifferentphasesofkawasakidisease(KD)andthe

controlgroup。Results①D-dimerofthepatientsofKDwerehighersignificantly

thanthatofthecontrolgroup(P＜0.01).②Accordingtothedynamicobservation,

theriseofD-dimerofpatientsofKDinlessthan7daysorbetween7to14dayshad

significantdifferencewiththecontrolgroup(P＜0.01),andhadnotsignificant

differenceafter14days(P＞0.05).③TheriseofD-dimerofpatientsofKDhadnot

significantdifferencebetweenCADgroupandNCADgroup(P＞0.05).④According

tothedynamicobservation,IthadnotsignificantdifferencebetweenCADgroupand

NCADgroupinlessthan7days(P＞0.05),andhadsignificantdifferencebetween7

to14days(P＜0.01)orafter14days(P＜0.05).ConclusionD-dimercanbeoneof

importantindexforearlydiagnosisofKD,andthedynamicobservationofD-dimer

canpredictthecoronaryarterylesions.

【Keywords】Dynamicobservation;Bloodcoagulation;Kawasaki

disease(KD);Earlydiagnosis;Coronaryarterylesions

川崎病(kawasakidisease,KD)又称皮肤黏膜淋巴结综合征,目前尚无可以早期

确诊的特异性手段。川崎病的冠状动脉并发症已取代风湿热成为儿童后天性心脏

病的主要病因[1]。本文通过