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Lecture5Pharmaceutics
bioavailabilitylysosomeconjugatepartitioncoefficientaerodynamicsantibodydrugconjugate(抗体药物偶联物)
permeabilityexcipientformulationparenteralheterogeneous
finishedpharmaceuticalproductphysiologicalfunctionsactivepharmaceuticalingredientbiologicsinactivebiologicalsystems
formulationsimplantssensitivitypackaging
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1.Whatarethepossibleroutesforenteraladministration?2.Whatarethepossibleroutesforparenteraladministration?
3.Whatisfirst-passeffect?Medicationsaremetabolizedbeforegainingtheirentrytickettothesystemiccirculation.
4.Whatisbioavailability?Itisameasureofabsorptionandreferstotheportionofamedicationthatreachesthesystemiccirculationwhenadministeredbynon-intravenousroutes.
5.Whatfactorsshouldbetakenintoaccountwhendecidingtherouteofadministration?----Thechemicalpropertiesofthemedicationitself,suchasitsstabilityanditsabilitytocrosscertainbarriersofabsorption.----First-passeffectandbioavailability.Drugswithextensivefirst-passmetabolismshouldn’tbeadministeredperorallyasitwoulddecreasetheirefficacy.----Anotherfactoristheurgencyofthesituation.Peroralmedicationsproduceaneffectmuchslowerthanintravenousonesandthusthelatterispreferredinemergencysettingsandduringsurgicalprocedures.
Howdobrainandanyotherorganinhumanbodygetoxygenandnutrients?----heartpumpsoxygenatedbloodintoarteries;----arteriesbranchoutintotinierandtinierbloodvesselscalledcapillaries;----capillariesdistributeintovarioustissues;----thethinwallsofcapillariesallowdiffusionofsubstancesacrossit.
WhatarethespecialstructurefeaturesthatmakeBBBhaveselectivepermeability?
WhatarethefunctionsoftransportersontheendotheliumofBBB?Theyletdifferentnutrientsinandwasteproductsout.
1.Whatinspiredthespeakertopursuetreatingbraindiseaseswithnewtherapeutics?Thetypicalexp
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