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RadioiodineTherapy
I-123(123I)-------diagnosticapplicationI-124(124I)-------PETscanI-125(125I)-------diagnosticandtherapeuticapplicationI-131(131I)RadioactiveIodine……
I-125(125I)
In1942HertzandRobertsHamiltonandJ.H.LawrencehyperthyroidismIn1943Seidlinetal.thyroidcarcinomaI-131(131I)
BenignThyroidDiseasesHyperthyroidism(Graves’disease)ToxicNodularGoiterNontoxicNodularGoiter
MalignantThyroidDiseaseDifferentiateThyroidCaner(DTC)papillarythyroidcancerfollicularthyroidcancermixtureofpapillaryandfollicularthyroidcancer
Iodine-131TherapyforHyperthyroidism
SIGNSANDSYMPTOMSSkin:IncreasedSweatingandheatintolerance,onycholysis,hyperpigmentation,pruritusandthinningofthehair.Eyes:Stareandlidlag,exophtalmosifgravesdiseaseCardiac:Palpitations,exertionaldyspnea,anginal-likechestpain,tachycardia,atrialfibrillation,CHFGI:Weightloss,diarrheaNeuro-psych:Anxiety,restlessness,irritability,emotionallability,psychosis,agitation,anddepressionMetabolic/Endocrine:Hyperglycemia,lowserumtotalandhigh-densitylipoprotein(HDL)cholesterol
GRAVES’DISEASESignsandsymptomsofhyperthyroidismExopthalmos,proptosis,lidlag,orbitaledemaDiffusegoiterTSHreceptorantibodiesIncreasedRAIuptake
Graves’ophthalmopathy
DiffuseGoiter
AntithyroidDrug(ATDs)methimazolepropylthiouracilSurgeryIodine-131Therapyforhyperthyroidism
TheATDsinhibitthyroidhormonebiosynthesis.Theyareusefuleitherasaprimaryformoftherapyortolowerthyroidhormonelevelsbeforeradioactiveiodinetherapyorsurgery.Long-termATDtherapymayleadtoremissioninsomepatientswithGraves’disease.Thereisnoclear-cutstandardfordurationoftherapywithATDS,butwhenusedasprimarytherapy,theyareusuallygivenfor6monthsto2years,althoughalongerperiodofadminis
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