结直肠癌患者血清白细胞介素6水平及与肿瘤疗效关系 .pdfVIP

结直肠癌患者血清白细胞介素6水平及与肿瘤疗效关系

陈岩松;陈燕;陈娜娟

【摘要】目的探讨人白细胞介素6(interleukin-6,IL-6)在结直肠癌患者中的水平

及意义.方法收集132例首诊结直肠癌患者(CRC)、35例炎症性肠病(IBD)、31例

肠道良性疾病患者(CBD)及84例健康体检者(HC)血清,采用电化学发光双抗体夹心

免疫分析法(ECLIA)检测血清中白细胞介素6(IL-6)及癌胚抗原(CEA)水平,分析IL-6

水平与结直肠癌患者临床病理特征的相关性;应用受试者工作特性曲线(ROC)和二

元Logistic法回归分析IL-6和CEA两指标对结直肠癌的诊断价值;对随访资料完

整的120例中晚期结直肠癌患者动态观察治疗前后血清IL-6和CEA水平,分析两

指标与肿瘤疗效的关系.结果结直肠癌患者血清IL-6水平显著高于炎症性肠病组(P

＜0.05)、肠道良性疾病组(P＜0.01)和健康对照组(P＜0.01),结直肠癌患者血清

CEA水平显著高于炎症性肠病组(P＜0.05)、肠道良性疾病组(P＜0.05)和健康对照

组(P＜0.01),差异均有统计学意义.CRC患者血清IL-6水平与肿瘤直径、分化程度、

组织类型、淋巴结转移、远处转移、TNM分期均显著相关(P＜0.05),而与年龄、

性别及肿瘤发生部位无明显相关.IL-6诊断结直肠癌的灵敏度(72.7％)和准确性

(78.6％)均高于CEA(分别为68.2％和77.9％),特异性(85.2％)低于CEA(88.9％),两

指标联合检测能够提高灵敏度(97.2％)和准确性(85.6％).结直肠癌肿瘤控制组(CR

+PR+SD)治疗后两指标均较治疗前有显著下降(P＜0.05),差异有统计学意义,而肿

瘤进展组(PD)治疗后两指标均未显著下降(P＞0.05).结论IL-6和CEA两指标联合

检测有助于结直肠癌的诊断和疗效观察.%ObjectiveToinvestigatethe

expressionofseruminterleukin-6(IL-6)incolorectalcancerpatientsand

therelationshipbetweentheIL-6levelandthetumorcurative

effect.MethodsTheelectrochemiluminescenceimmunoassaywasusedto

examinetheserumlevelofIL-6andcarcino-embryonicantigen(CEA)in

132colorectalcancerpatients(CRC),35inflammatoryboweldisease

(IBD),31colorectalbenigndisease(CBD)and84healthydonorsashealthy

controlgroup(HC).TherelationshipbetweenIL-6andclinicopathological

featuresofcolorectalcancerwasanalyzed,andROCcurveandbinary

losisticregressionwereappliedtocomparethediagnosticvalueoftheIL-6

andCEA.ThedynamiclevelsofserumIL-6andCEAbeforeandafter

treatmentin120advancedCRCpatientswithcompletecasedatawas

observed,andtherelationshipbetweenIL-6andCEAandthecruative

effectofthetumorwasanalyzed.ResultsBoththeserumIL-6andCEA

levelsoftheCRCwerehigherthanIBD(P＜0.05,P＜

0.05,respectively),CBD(P＜0.01,P＜0.05,respectively),andHCgroups(P

＜0.01,P＜0.01,respectively