E-Z-N-Desethylsunitinib-hydrochloride-E-Z-SU-12662-hydrochloride-生命科学试剂-MCE.pdf

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(E/Z)-N-Desethylsunitinibhydrochloride

Cat.No.:HY-138813A

CASNo.:1261432-05-6

Synonyms:(E/Z)-SU-12662hydrochloride

分⼦式:C₂₀H₂₄ClFN₄O₂

分⼦量:406.88

作⽤靶点:Others

作⽤通路:Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(E/Z)-N-Desethylsunitinibhydrochloride((E/Z)-SU-12662hydrochloride)是⼀种具有潜在抗肿瘤活性的化合

物，能够抑制VEGF-R2和PDGF-Rβ酪氨酸激酶。(E/Z)-N-Desethylsunitinibhydrochloride是舒尼替尼的主要

活性代谢产物，具备竞争性抑制ATP的能⼒。

REFERENCES

[1].Discoveryof5-[5-fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl]-2,4-dimethyl-1H-pyrrole-3-carboxylicacid(2-

diethylaminoethyl)amide,anoveltyrosinekinaseinhibitortargetingvascularendothelialandplatelet-derivedgrowthfactorreceptortyrosine

kinase

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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