Minocycline-d7-生命科学试剂-MCE.pdf

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Inhibitors•ScreeningLibraries•Proteins

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Minocycline-d7

Cat.No.:HY-W654013

分⼦式:C₂₃H₂₀D₇N₃O₇

分⼦量:464.52

作⽤靶点:Isotope-LabeledCompounds;CalciumChannel;HIF/HIF

Prolyl-Hydroxylase;MDM-2/p53;Bacterial;Antibiotic;

PotassiumChannel;Apoptosis

作⽤通路:Others;MembraneTransporter/IonChannel;Neuronal

Signaling;MetabolicEnzyme/Protease;Apoptosis;Anti-

infection

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Minocycline-d7是氘代标记的Minocycline。Minocycline是⼀种⼝服有效、能透过⾎脑屏障的半合成四环素

类抗⽣素。Minocycline是⼀种缺氧诱导因⼦(HIF-1α)抑制剂。Minocycline具有抗癌(anti-cancer)，抗炎(

anti-inflammatory)和⾕氨酸(glutamate)拮抗作⽤。Minocycline降低⾕氨酸神经传递，显⽰神经保护特性

和抗抑郁作⽤。Minocycline通过与细菌核糖体30S亚基结合，抑制细菌蛋⽩的合成，从⽽产⽣抑菌(

bacteriostatic)作⽤。

REFERENCES

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[2].XuL,etal.Lowdoseintravenousminocyclineisneuroprotectiveaftermiddlecerebralarteryocclusion-reperfusioninrats.BMCNeurol.

2004Apr26;4:7.

[3].ZhangL,etal.Protectiveeffectsofminocyclineonbehavioralchangesandneurotoxicityin