Peptide-P60-FOXP3-inhibitor-P60-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

PeptideP60

Cat.No.:HY-P1684

CASNo.:1319725-20-6

Synonyms:FOXP3inhibitorP60

分⼦式:C₉₅H₁₃₂N₂₄O₂₀S₂

分⼦量:1994.34

Sequence:Arg-Asp-Phe-Gln-Ser-Phe-Arg-Lys-Met-Trp-Pro-Phe-Phe-Ala-

Met

SequenceShortening:RDFQSFRKMWPFFAM

作⽤靶点:NF-κB;NuclearFactorofactivatedTCells(NFAT)

作⽤通路:NF-κB;Immunology/Inflammation

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PeptideP60是⼀种FOXP3抑制剂。PeptideP60能够进⼊细胞，抑制FOXP3的核转位，并降低其抑制转录因

⼦NF-κB和NFAT的能⼒。PeptideP60能够抑制⼩⿏和⼈类来源的调节性T细胞(Treg)的免疫抑制活性

，并在体外增强效应T细胞的刺激。PeptideP60可诱发⼀种淋巴增⽣性⾃⾝免疫综合征，其病理表现与报道

的缺乏功能性Foxp3的斑驳⿏相似。PeptideP60可以提⾼癌症和病毒疫苗的免疫原性[1]。

REFERENCES

[1].CasaresN,etal.ApeptideinhibitorofFOXP3impairsregulatoryTcellactivityandimprovesvaccineefficacyinmice[J].TheJournalof

Immunology,2010,185(9):5150-5159.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.