人体结构与功能 5-Elements of cellular and molecular neuroscience-excitability学习资料.ppt

****************************************************************************************************************************CholinergicAgonistsDirect Muscarine NicotineIndirect AChEInhibitors~CholinergicAntagonistsDirect Nicotinic-Curare Muscarinic-Atropine Ligand-OperatedAChChannelsNReceptorGProtein-OperatedAChChannelMreceptor(2)MonoaminesasNTMonoaminesCatecholamines– Dopamine-DA Norepinephrine-NE Epinephrine-EIndolamines-Serotonin-5-HTMechanismofAction(?receptor)Epia1GproteinPLCIP3Ca+2Norepinephrine(NE)asNTNTinbothPNSandCNS.PNS:Smoothmuscles,cardiacmuscleandglands.Increaseinbloodpressure,constrictionofarteries.CNS:Generalbehavior.AdrenergicNeurotransmission?1ReceptorStimulatedbyNE,E,bloodvesselsofskin,mucosa,abdominalviscera,kidneys,salivaryglandsvasoconstriction,sphincterconstriction,pupildilationAdrenergicNeurotransmission?2Receptorstimulatedby,NE,E,…..Membraneofadrenergicaxonterminals(pre-synapticreceptors),plateletsinhibitionofNErelease(autoreceptor),promotesbloodclotting,pancreasdecreasedinsulinsecretionAdrenergicNeurotransmission?1receptorstimulatedbyE,….Mainlyheartmusclecells,increasedheartrateandstrengthAdrenergicNeurotransmission?2receptorstimulatedbyE..Lungs,mostothersympatheticorgans,bloodvesselsservingtheheart(coronaryvessels),dilationofbronchiolesbloodvessels(coronaryvessels),relaxationofsmoothmuscleinGItractandpregnantuterusAdrenergicNeurotransmission?3receptorstimulatedbyE,….Adiposetissue,stimulationoflipolysis(3)AminoAcidsasNTGlutamateacidandaspartateacid:ExcitatoryAminoAcid(EAA)gamma-amino-butyricacid(GABA)andglycine:InhibitoryAA(4)PolypeptidesasNTCCK:Promot