乙酰辅酶A羧化酶相关树突状细胞标记预测肝癌患者的预后及潜在治.docx

乙酰辅酶A羧化酶相关树突状细胞标记预测肝癌患者的预后及潜在治疗药物识别

闫长孟韩君

[关键词]?肝癌；乙酰辅酶A羧化酶；预后；免疫细胞；DCs细胞标记基因

[中图分类号]?R735.7????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.05.018

Prediction?of?prognosis?and?identification?of?potential?therapeutic?agents?for?liver?cancer?patients?based?on?acetyl-coa?carboxylase?1-associated?dendritic?cell

YAN?Changmeng1，?HAN?Jun2

1.Department?of?Gastroenterology，?Huludao?Central?Hospital，?Huludao?125000，?Liaoning，?China;?2.Traditional?Chinese?Medicine?Research?Institute，?Beijing?Tcmages?Pharmaceutical?Co.，?Ltd.，?Beijing?101301，?China

[Abstract]?Objective?To?investigate?the?expression，?prognostic?value?of?acetyl-coa?carboxylase?1?（ACACA）?gene?in?liver?cancer，?its?correlation?with?immune?cells，?and?to?construct?a?prognostic?model.?Methods?Integrating?genotype-tissue?expression?（GTEx）?and?the?cancer?genome?atlas?（TCGA）?data?to?analyze?ACACA?expression?in?cancers?and?adjacent?tissues，?and?perform?prognosis?analysis.?Examine?the?correlation?between?ACACA?and?immune?cells.?Use?GSE156625?cell?RNA?seq?（scRNA-seq）?data?to?study?ACACA?expression?in?dendritic?cells?（DCs）.?Construct?an?hepatocellular?carcinoma?（HCC）?prognosis?model?based?on?apolipoprotein?c-Ⅰ（APOC1）?and?apolipoprotein?c-Ⅲ?（APOC3），?using?Kaplan-Meier?survival?curves?and?time-dependent?receiver?operator?characteristic?（ROC）?curves?to?evaluate?prognostic?capability，?and?analyze?the?effect?of?traditional?Chinese?medicine?components?on?APOC1?and?APOC3?through?molecular?docking.?Results?ACACA?shows?significant?differential?expression?in?various?cancers?and?is?associated?with?the?prognosis?of?liver?cancer.?High?expression?of?ACACA?reduces?the?content?of?dendritic?cells.?APOC1?and?APOC3，?the?major?DCs?marker?genes，?were?positively?correlated?with?ACACA?expression.?Using?Kaplan-Meier?curves，?we?predicted?the?1-year，?3-year，?and?5-year?overall?survival?（OS）?probabilities?for?HCC?patients?in?the?TCGA?cohort，?and?confirmed?the?reliability?through?calibration?curve?analysis.?Salvianolic?acid?B，?Asiaticoside，?and?Ne