瑞马唑仑对老年患者无痛支气管镜检查的麻醉效果影响.docx

瑞马唑仑对老年患者无痛支气管镜检查的麻醉效果影响

张学湖徐振东陈佩佩熊俊成潘宗怀

[关键词]?瑞马唑仑；无痛支气管镜；麻醉效果；认知功能；炎症因子

[中图分类号]?R743????[文献标识码]?A????[DOI]?10.3969/j.issn.1673-9701.2024.03.016

Effect?of?remimazolam?on?anesthetic?efficacy?of?painless?bronchoscopy?in?elderly?patients

ZHANG?Xuehu，?XU?Zhendong，?CHEN?Peipei，?XIONG?Juncheng，?PAN?Zonghuai

Department?of?Anesthesiology，?Wenzhou?People’s?Hospital，?Wenzhou?325000，?Zhejiang，?China

[Abstract]?Objective?To?investigate?the?effect?of?remimazolam?on?anesthetic?effect?and?postoperative?cognitive?function?during?painless?bronchoscopy?in?elderly?patients.?Methods?A?total?of?90?patients?with?painless?bronchoscopy?admitted?to?Wenzhou?People’s?Hospital?were?selected.?And?randomly?dividing?into?45?patients?in?control?group，?45?patients?in?observation?group.?The?control?group?was?given?propofol，?and?the?observation?group?was?given?remimazolam.?Mean?arterial?pressure?（MAP），?heart?rate?（HR），?and?blood?oxygen?saturation?（SpO2）?were?monitored.?Effective?time?after?induction，?recovery?time?after?withdrawal?and?discharge?time?were?compared.?Patient’s?cognitive?function?was?assessed?using?the?mini-mental?state?examination?（MMSE），?auditory?word?learning?test?（AVLT），?shape?connection?test?（STT），?and?animal?language?fluency?test?（AFT）.?Enzyme?linked?immunosorbent?assay?（ELISA）?was?used?to?determine?substance?P?（SP），?C-reactive?protein?（CRP），?noradrenaline?（NE），?tumor?necrosis?factor-α?（TNF-α）?in?serum，?interleukin?（IL）-6?and?prostaglandin?E2?（PGE2）?concentrations.?Results?Compared?with?the?control?group，?the?MAP?of?the?observation?group?patients?at?time?points?T2?and?T3?showed?statistically?significant?differences?（P0.05）;?HR?was?especially?significant?at?T2，?T3?and?T6?periods?（P0.05）.?SpO2?at?T2?and?T3?（P0.05）.?The?awakening?time，?discharge?time?of?the?observation?were?shorter?than?control?（P0.05）.?At?1?day?after?surgery，?the?MMSE?score，?STT?score，?AFT?score?were?significantly?higher?（P0.05）;?The?serum?levels?of?SP，?PGE2?and?NE?and?IL-6，?TNF-α?and?CRP?were?decreased?in?the?