老年2型糖尿病患者骨骼肌质量与内脏脂肪面积比值和心血管疾病风.docx

老年2型糖尿病患者骨骼肌质量与内脏脂肪面积比值和心血管疾病风险的相关性分析

[关键词]2型糖尿病；骨骼肌质量与内脏脂肪面积比值；心血管疾病；风险评估；中国动脉粥样硬化性心血管疾病风险预测研究

[中图分类号]R587.2[文献标识码]A[DOI]10.3969/j.issn.1673-9701.2025.03.011

[Abstract]ObjectiveToexploretherelationshipbetweenskeletalmusclemasstovisceralfatarearatio（SVR）andcardiovasculardisease（CVD）riskinelderlypatientswithtype2diabetesmellitus（T2DM）.Methods144T2DMpatientswhovisitedtheDepartmentofGeriatrics，theFirstAffiliatedHospitalofSoochowUniversityfromOctober2022toDecember2023wereselectedtoevaluateSVRbasedonbioelectricalimpedancemeasurements.TheriskmodelofpredictionforASCVDriskinChina（China-PAR）wasusedtoassesstheriskofcardiovasculardiseaseinT2DMpatients.StatisticalanalysisofthecorrelationbetweenSVRandChina-PARriskscores.ResultsTheCVDriskscoreofT2DMpatientsincreasedwiththedecreaseofSVR（Plt;0.001）.TheSVRofhigh-riskgrouppatientswaslowerthanthatoflow-riskgrouppatients，andtheirwaistcircumferencewashigherthanthatoflow-riskgrouppatients，withstatisticalsignificance（Plt;0.05）.TherewasnostatisticallysignificantdifferenceinBMIbetweentwogroupsofpatients（P=0.1229）.Afteradjustingforconfoundingfactors，therewasanindependentcorrelationbetweenSVRandChinaPARriskscores（β=–2.744，P=0.007）.ConclusionT2DMpatientswithlowerSVRhaveahigherriskofdevelopingCVD，andSVRlevelsaresignificantlynegativelycorrelatedwithCVDriskinelderlyT2DMpatients.SVRmaybeavaluableparameterforassessingCVDriskintheelderly.

[Keywords]Type2diabetesmellitus;Skeletalmusclemasstovisceralfatarearatio;Cardiovasculardiseases;Riskassessment;PredictionforASCVDriskinChina

1资料与方法

1.1一般资料

1.2纳入及排除标准

1.3观察指标

1.3.1临床指标测量患者均接受全面体检，按标准化方法测量腰围、体质量和身高。计算体质量指数（bodymassindex，BMI）。休息至少5min后测量两次血压，计算平均值。

患者的血样本在隔夜禁食10h后采集。在本院实验室进行血液分析，检测空腹血糖（fastingplasmaglucose，FPG）、尿酸、白蛋白、肌酐、低密度脂蛋白胆固醇（low-densitylipoprote