TYD-68-生命科学试剂-MCE.pdf

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

TYD-68

Cat.No.:HY-173357

分⼦式:C₄₃H₄₀FN₁₁O₇

分⼦量:841.85

作⽤靶点:PROTACs;JAK;STAT

作⽤通路:PROTAC;Epigenetics;JAK/STATSignaling;ProteinTyrosine

Kinase/RTK;StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性TYD-68是⼀种⾼效且选择性的CRBN招募型TYK2PROTAC降解剂，其DC50值为0.42nM。TYD-68能够通过

泛素-蛋⽩酶体途径选择性降解TYK2蛋⽩，并显著抑制IL-12和IFN-α诱导的STAT4和STAT1磷酸化，从⽽

阻断TYK2依赖性信号通路。TYD-68可⽤于银屑病的研究。(Pink:靶蛋⽩配体(HY-173359);Black:Linker(HY-

W007732B);Blue:E3连接酶配体(HY-14658);E3连接酶配体+Linker(HY-173358))[1]。

IC50TargetDC50:0.42nM(TYK2)[1].

REFERENCES

[1].XiongS,etal.DiscoveryofaHighlyPotentandSelectiveTyrosineKinase2(TYK2)DegraderwithInVivoTherapeuticEfficacyina

MurinePsoriasisModel.JMedChem.2025Apr10;68(7):7560-7578.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:4