PI-103-Standard-生命科学试剂-MCE.pdfVIP

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PI-103(Standard)

Cat.No.:HY-10115R

CASNo.:371935-74-9

分⼦式:C₁₉H₁₆N₄O₃

分⼦量:348.36

作⽤靶点:PI3K;mTOR;DNA-PK;Autophagy;Apoptosis

作⽤通路:PI3K/Akt/mTOR;CellCycle/DNADamage;Autophagy;

Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性PI-103(Standard)是PI-103的分析标准品。本产品⽤于研究及分析应⽤。PI-103是⼀种有效的PI3K和mTOR

抑制剂，抑制p110α，p110β，p110δ，p110γ，mTORC1和mTORC2，IC50分别为8nM，88nM，48

nM，150nM，20nM和83nM。PI-103还抑制DNA-PK，IC50为2nM。PI-103诱导⾃噬(autophagy)[1]

[2][3][4]。

IC50TargetIC50:8nM(p110α),88nM(p110β),48nM(p110δ),150nM(p110γ),2nM(DNA-PK),20nM(mTORC1),83

nM(mTORC2),26nM(PI3KC2β),850nM(ATR),920nM(ATM),~1μM(PI3KC2α),2.3μM(hsVPS34),~50

μM(PI4KIIIβ)[4]

REFERENCES

[1].RaynaudFI,etal.BiologicalpropertiesofpotentinhibitorsofclassIphosphatidylinositide3-kinases:fromPI-103throughP