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4-IBP(Standard)

Cat.No.:HY-100155R

CASNo.:155798-08-6

分⼦式:C₁₉H₂₁IN₂O

分⼦量:420.29

作⽤靶点:SigmaReceptor;ReferenceStandards;Apoptosis;Autophagy

作⽤通路:NeuronalSignaling;Others;Apoptosis;Autophagy

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性4-IBP(Standard)是4-IBP(HY-100155)的分析标准品。本产品⽤于研究及分析应⽤。4-IBP是⼀种选择性σ₁

受体(σ₁receptor)激动剂，对σ₁受体具有⾼亲和⼒（Ki=1.7nM），对σ₂受体具有中等亲和⼒(Ki=25.2

nM)。4-IBP可以使癌细胞对促凋亡(pro-apoptotic)和促⾃噬(pro-autophag

REFERENCES

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andsensitizestheminvitroandinvivotocytotoxicinsultsofproapoptoticandproautophagicdrugs.Neoplasia.2007May;9(5):358-69.

[2].BermackJE,etal.Modulationofserotonergicneurotransmissionbyshort-andlong-termtreatmentswithsigmaligands.BrJPharmacol.

2001Oct;134(3):691-9.

[3].DebeirO,etal.Videomicroscopicextractionofspe