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Alrizomadlin(Standard)

Cat.No.:HY-101518R

CASNo.:1818393-16-6

分⼦式:C₃₄H₃₈Cl₂FN₃O₄

分⼦量:642.59

作⽤靶点:MDM-2/p53;ReferenceStandards;E1/E2/E3Enzyme;

Apoptosis

作⽤通路:Apoptosis;Others;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Alrizomadlin(Standard)是Alrizomadlin(HY-101518)的分析标准品。本产品⽤于研究及分析应⽤。

Alrizomadlin(APG-115)是⼀种⼝服活性⼩分⼦MDM2蛋⽩抑制剂,可与MDM2蛋⽩结合，IC50值和Ki值分

别为3.8nM和1nM。Alrizomadlin可阻断MDM2与p53的相互作⽤并且以p53依赖性⽅式诱导细胞周期停

IC50TargetIC50:3.8nm(APG-115)[1]

REFERENCES

[1].AngeloAguilar,etal.4-((3′R,4′S,5′R)-6″-Chloro-4′-(3-chloro-2-fluorophenyl)-1′-ethyl-2″-oxodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-

indoline]-5′-carboxamido)bicyclo[2.2.2]octane-1-carboxylicAcid(AA-115/APG-115):APotentandOrallyActiveMurineDoubleMinute2

(MDM2)InhibitorinClinicalDevelopment.JMedChem.2017Apr13;60(7):2819–2839.

[2].AWTolcheretal,AphaseIb/IIstudyofAPG-11