BR101549-生命科学试剂-MCE.pdfVIP

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BR101549

Cat.No.:HY-123974

CASNo.:2252478-54-7

分⼦式:C₃₀H₃₄N₄O₅

分⼦量:530.61

作⽤靶点:PPAR

作⽤通路:CellCycle/DNADamage;MetabolicEnzyme/Protease;Vitamin

DRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性BR101549是⼀种⾮噻唑烷⼆酮类过氧化物酶体增殖物激活受体γ(PPARγ)激动剂。BR101549在体外激活

PPARγ的活性与吡格列酮相当。BR101549可以控制⼩⿏模型的⾎糖⽔平。BR101549可⽤于抗糖尿病研究

[1]。

REFERENCES

[1].Choung,W.,etal.,(2019).IdentificationofBR101549asaleadcandidateofnon-TZDPPARγagonistforthetreatmentoftype2

diabetes:Proof-of-conceptevaluationandSAR.Bioorganicmedicinalchemistryletters,29(4),631-637.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

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