D-Alanine-13C3-R-Alanine-sup-13-sup-C-sub-3-sub-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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D-Alanine-13C3

Cat.No.:HY-41700S5

CASNo.:286460-72-8

Synonyms:(R)-Alanine-13C;Ba2776-13C;D-α-Alanine-13C

333

分⼦式:₁₃C₃H₇NO₂

分⼦量:92.07

作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite

作⽤通路:Others;MetabolicEnzyme/Protease

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性D-Alanine-13C3((R)-Alanine-13C3)是13C标记的D-Alanine(HY-41700)。D-Alanine(((R)-Alanine))是GlyR

和PMBA的弱激动剂，其对GlyR的EC50值为9mM。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].SchmiedenV,etal.Pharmacologyoftheinhibitoryglycinereceptor:agonistandantagonistactionsof