D-Arg1-D-Trp5-7-9-Leu11-Substance-P-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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[D-Arg1,D-Trp5,7,9,Leu11]-SubstanceP

Cat.No.:HY-P11405

CASNo.:122481-75-8

分⼦式:C₈₁H₁₁₀N₂₀O₁₂

分⼦量:1555.87

Sequence:{d-Arg}-Pro-Lys-Pro-{d-Trp}-Gln-{d-Trp}-Phe-{d-Trp}-Leu-Leu-

NH2

SequenceShortening:{d-Arg}-PPKP-{d-Trp}-Q-{d-Trp}-F-{d-Trp}-LL-NH2

作⽤靶点:NeurotensinReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性[D-Arg1,D-Trp5,7,9,Leu11]-SubstanceP，⼀种强效的⼩细胞肺癌(SCLC)细胞⽣长抑制剂。[D-Arg1,D-

Trp5,7,9,Leu11]-SubstanceP也是⼀种神经肽拮抗剂，能阻断多种神经肽(包括⾎管加压素和缓激肽)刺激的集

落形成。[D-Arg1,D-Trp5,7,9,Leu11]-SubstanceP抑制了⾎管加压素或缓激肽诱导的Ca2+动员和丝裂原活化

蛋⽩激酶的激活。[D-Arg1,D-Trp5,7,9,Leu11]-SubstanceP抑制裸⿏体内H-69异种移植瘤的⽣长。

REFERENCES

[1].SecklMJ,etal.[D-Arg1,D-Trp5,7,9,Leu11]substanceP:anovelpotentinhibitorofsignaltransductionandgrowthinvitroandinvivoin

smallcelllungcancercells.CancerRes.1997Jan1;57(1):51-4.

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Caution:Producthasnotbeenfullyvalidatedformedicalapplications.