Danitracen-NSC-170955-生命科学试剂-MCE.pdfVIP

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Danitracen

Cat.No.:HY-105704

CASNo.:31232-26-5

Synonyms:NSC170955;WA335

分⼦式:C₂₀H₂₁NO

分⼦量:291.39

作⽤靶点:5-HTReceptor

作⽤通路:GPCR/GProtein;NeuronalSignaling

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Danitracen(NSC170955)是⼀种⼝服有效的、可透过⾎脑屏障的⾎清素(serotonin)拮抗剂，具有抗抑郁活性

。Danitracen可降低⼤脑、⼩脑、延髓和全脑中的⾎清素⽔平。Danitracen在⼤⿏僵直症模型中表现出抗僵

直作⽤。Danitracen可⽤于僵直症和抑郁症的研究[1][2][3]。

REFERENCES

[1].MajJ,etal.InfluenceofWA-335,afactorwhichblocksserotoninreceptors,onneuroleptic-inducedcatalepsy.ArchImmunolTherExp

(Warsz).1976;24(2):197-203.

[2].KaumeierS,etal.WA335(danitracen):apreliminaryevaluationofapotentialantidepressantcompound.Acomparativedouble-blind

studywithWA335andamitriptylineinthetreatmentofdepressivepatients.CurrTherResClinExp.1977Jan;21(1):108-13.

[3].MajJ,etal.InfluenceofWA-335,afactorwhichblocksserotoninreceptors,onneuroleptic-inducedcatalepsy.ArchImmunolTherExp

(Warsz).1976;2