Dasatinib-GMP-Like-BMS-354825-GMP-Like-生命科学试剂-MCE.pdfVIP

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Dasatinib(GMPLike)

Cat.No.:HY-10181GL

CASNo.:302962-49-8

Synonyms:BMS-354825(GMPLike)

分⼦式:C₂₂H₂₆ClN₇O₂S

分⼦量:488.01

作⽤靶点:Bcr-Abl;Src;Autophagy;Apoptosis

作⽤通路:ProteinTyrosineKinase/RTK;Autophagy;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性Dasatinib(GMPLike)(BMS-354825(GMPLike))是GMPLike级别的Dasatinib(HY-10181)。GMPLike级别的

⼩分⼦可⽤做细胞疗法中的辅助试剂。Dasatinib(BMS-354825)是⼀种具有⼝服活性的，ATP竞争性的，双重

Src/Bcr-Abl抑制剂，具有有效的抗肿瘤活性。对Src和Bcr-Abl的Ki值分别为16pM和30pM。Dasatinib抑

制Bcr-Abl和Src的IC50分别为[1]。Dasatinib还诱导凋亡(apoptosis)和⾃噬(autophagy)。

体外研究Dasatinib(GMPLike)demonstratessignificantactivityagainstBcr-Abl,Src,Lck,Yes,c-Kit,PDGFRβ,p38,

Her1,Her2,FGFR-1,andMEKwithIC50sof[1].

Dasatinib(GMPLike)showsantiproliferativeactivitiesaversusK562chronicmyelogenousleukemia(CML),

PC3humanprostatetumor,MDA-MB-231humanbreasttumor,andWiDrhumancolontumorcelllineswith

IC50sof[1].

体内研究Dasatinib(GMPLike)(5mg/kgand50mg/kg,qd×10d,5on-2off)possessespotentantitumoractivityanda