DBCO-NHCO-PEG4-amine-TFA-生命科学试剂-MCE.pdfVIP

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DBCO-NHCO-PEG4-amineTFA

Cat.No.:HY-124386A

分⼦式:C₃₁H₃₈F₃N₃O₈

分⼦量:637.64

作⽤靶点:ADCLinker;PROTACLinkers

作⽤通路:Antibody-drugConjugate/ADCRelated;PROTAC

储存⽅式:Pureform-20°C3years

Insolvent-80°C6months

-20°C1month

BIOLOGICALACTIVITY

⽣物活性DBCO-NHCO-PEG4-amineTFA是⼀种PROTAC连接⼦(PROTACLinker)，属于PEG类。DBCO-NHCO-PEG4-

amineTFA是⼀种可降解(cleavable)的ADClinker，可⽤于连接MMAE(HY-15162)和抗体(例如DBCO-

VCpABMMAE和DBCO-TRXMMAE，对SKBR3细胞的EC50分别为280nM和22nM)[1]。

IC50TargetPEGsCleavableLinker

REFERENCES

[1].SpanglerB,etal.TowardaFerrousIron-CleavableLinkerforAntibody-DrugConjugates.MolPharm.2018May7;15(5):2054-2059.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

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