DDC4002-生命科学试剂-MCE.pdfVIP

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DDC4002

Cat.No.:HY-180325

CASNo.:2375048-04-5

分⼦式:C₂₀H₁₅FN₂O

分⼦量:318.35

作⽤靶点:EGFR

作⽤通路:JAK/STATSignaling;ProteinTyrosineKinase/RTK

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性DDC4002是⼀种选择性EGFR抑制剂。DDC4002对L858R/T790M突变EGFR亚型有抑制活性(IC50=39

nM)。

REFERENCES

[1].DeClercqDJH,etal.DiscoveryandOptimizationofDibenzodiazepinonesasAllostericMutant-SelectiveEGFRInhibitors.ACSMed

ChemLett.2019Oct22;10(11):1549-1553.

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1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师