复旦 高分子化学课件for copy-dendrimers.pptVIP

FUDANDendrimers

Tree-likemolecule?34

“Dendrimers”innatureFUDANPleomeleangustifolia(龙血树)

“Dendrimers”innatureFUDAN34

Topologicalstructuresofpolymers

Howtosynthesizedendrimers?DivergentConvergentBycascadereactions:Topologicalconsiderations

FUDANExamplesofimportantsynthesisofdendrimersSomearecommercialized

Poly(propyleneimine):PPIbydivergentFUDANV?gtleetalDivergentrouteAstramolTMbyDSM

PhysicalpropertyofPPIFUDANPPIinTHF

FirstfullpaperwenttoPJFUDAN

FUDAN34Typicalexamples:PAMAMbydivergent0-40?CAminedroppedtoesterYield95%0-40?C1droppedtoamineAmine50foldinexcess98%TomaliaetalDivergentroute

PAMAMFUDANStarburst?表面官能化：

FunctionalizedPAMAMFUDAN

FUDANPAMAMisnanosizedmolecule

PAMAMpropertiesFUDAN

LaboratorysynthesisFUDANtedious!

FUDANTypicalexamplesofsynthesis:convergentFrechetetalConvergentroute

ConvergentsynthesisFUDANDendriticaliphaticether

CharacterizationofdendrimersFUDANByMALDI-TOFMS:

CharacterizationofdendrimersFUDANByAFM:DilutesolutiononmicaSpincoatingonmica

CharacterizationofdendrimersFUDANPAMAMforG5toG10:

characterizationofdendrimersFUDANDiametersarealwayslargerthanheightindicatethatdendrimersaredomelikeinshapeonmicaSurface.

ShapeofdendrimersFUDANTheshapeofdendrimersdependsongeneration.

ThestructureofdendrimersFUDANHighprecisePerfectionWell-defineddeGennesdensepacking

ComparisonbetweenlinearanddendrimerFUDANLinear:1.Randomcoil;2.(semi)crystaline;HighTg;3.Lowersolubility;4.Viscosity~MW5.Non-Newtonianfluid(entanglement)6.Reptationmobility;(segmental)7.Anisotropicelectricconductivity;8.Polydisperse.Dendrimer:1.PredictableshapechangeasafunctionofMWandcore2.Amorphous;lowTg;3.Increasedsolubility;4.Viscosity~MW;5.Newtonianfluid;6.Mobilityasawhole;7.Isotropicelectricconductivity;8.Monodisperse.

ApplicationofdendrimersFUDANHost-guestchemistry:Docavityexistsindendrimers?Theprese