IPI-269609-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

IPI-269609

Cat.No.:HY-13654

CASNo.:878204-96-7

分⼦式:C₂₈H₄₁NO₂

分⼦量:423.63

作⽤靶点:Smo;Hedgehog

作⽤通路:StemCell/Wnt

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性IPI-269609是⼀种⼝服有效的Smoothened(SMO)抑制剂，靶向Hedgehog(Hh)信号通路。IPI-269609特异

性减少ALDH-bright(⾼醛脱氢酶活性)细胞亚群，这些细胞被认为是胰腺癌中的“癌症⼲细胞”。IPI-269609

显著抑制胰腺癌细胞的迁移与克隆形成。IPI-269609在⼩⿏模型中有效抑制胰腺癌转移。IPI-269609可⽤于胰

腺癌研究。

REFERENCES

[1].FeldmannG,etal.Anorallybioavailablesmall-moleculeinhibitorofHedgehogsignalinginhibitstumorinitiationandmetastasisin

pancreaticcancer.MolCancerTher.2008Sep;7(9):2725-35.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—您⾝边的抑制剂⼤师