M464-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

M464

Cat.No.:HY-179494

分⼦式:C₂₃H₂₈O₄S₃

分⼦量:464.66

作⽤靶点:NOD-likeReceptor(NLR);Pyroptosis;Caspase;Interleukin

Related;ReactiveOxygenSpecies(ROS)

作⽤通路:Immunology/Inflammation;Apoptosis;Metabolic

Enzyme/Protease;NF-κB

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性M464是⼀种⾮甾体类抗炎化合物，是⼀种强效且⼝服有效的NLRP3炎症⼩体抑制剂。M464通过抑制ASC寡

聚化和减少ROS的产⽣，抑制细胞焦亡(pyroptosis)，并阻断下游Caspase-1的表达和IL-1β的释放。M464

对⼩⿏急性肺损伤和肝损伤具有保护作⽤。M464可⽤于NLRP3相关炎症性疾病的研究[1]。

IC50TargetNLRP3inflammasome

体外研究M464(3-12μM)inhibitstheexpressionofmarkerproteinsassociatedwithNLRP3inflammasomeactivation

(IL-1βandCaspase-1),andrestrainstheproductionofintracellularROSandtheformationofASColigomers

inJ774A.1andTHP-1cells[1].

M464(3-12μM;1h)inhibitspyroptosisinmacrophagestriggeredbytheNLRP3inflammasomestimulatorin

J774A.1andTHP-1cells[1].

体内研究M464(15,30,60mg/kg;i.g.;singledose;1hourbeforeLPSinjection)mitigatesLPS(HY-D1056)-induced

acutelunginjuryinmicebyinhibitingNLRP3inflammasomeactivation[1].