LSD1-IN-46-生命科学试剂-MCE.pdfVIP

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LSD1-IN-46

Cat.No.:HY-179339

CASNo.:2982716-97-0

分⼦式:C₂₂H₂₉N₃O

分⼦量:351.49

作⽤靶点:HistoneDemethylase

作⽤通路:Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LSD1-IN-46是⼀种强效且具有⼝服活性的赖氨酸特异性去甲基化酶1(LSD1)抑制剂，IC50值为0.082μM。

LSD1-IN-46可阻断β-catenin介导的转录程序，从⽽抑制胃癌细胞的⼲性。LSD1-IN-46具有显著的抗肿瘤活

性，可⽤于胃癌的研究。

IC50TargetLSD1

0.082μM(IC50)

体外研究LSD1-IN-46(CompoundX-1)(0.5-2μM;5days)increasesH3K4me1/2levelsinMKN-45cellsandthiseffect

isabsentinLSD1-KOcells[1].

LSD1-IN-46(0.5-2μM;5days)inhibitsself-renewal,sphereformationandcolonyformationofMKN-45cells,

anddownregulatestheexpressionofβ-catenin,c-MycandstemnessmarkersOCT4,NANOG,SOX2[1].

WesternBlotAnalysis[1]

CellLine:MKN-45

Concentration:0.5,1,2μM

IncubationTime:5days

Result:DecreasedOCT4,NANOG,andSOX2levles.

Downregulatedtheexpressionofβ-catenin,c-Myc.

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