L-Proline-d4-生命科学试剂-MCE.pdfVIP

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L-Proline-d4

Cat.No.:HY-Y0252S8

分⼦式:C₅H₅D₄NO₂

分⼦量:119.16

作⽤靶点:Isotope-LabeledCompounds;EndogenousMetabolite;

Apoptosis;mTOR

作⽤通路:Others;MetabolicEnzyme/Protease;Apoptosis;

PI3K/Akt/mTOR

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性L-Proline-d4是L-Proline(HY-Y0252)的氘代物。L-Proline是⼈体中⼆⼗种氨基酸之⼀，⽤于构建蛋⽩质。

体外研究Stableheavyisotopesofhydrogen,carbon,andotherelementshavebeenincorporatedintodrugmolecules,

largelyastracersforquantitationduringthedrugdevelopmentprocess.Deuterationhasgainedattention

becauseofitspotentialtoaffectthepharmacokineticandmetabolicprofilesofdrugs.

REFERENCES

[1].LiH,etal.,l-ProlineAlleviatesKidneyInjuryCausedbyAFB1andAFM1throughRegulatingExcessiveApoptosisofKidneyCells.

Toxins(Basel).2019Apr16;11(4):226.

[2].WashingtonJM,etal.,L-ProlineinducesdifferentiationofEScells:anovelroleforanaminoacidintheregulationofplur