LRH-1-antagonist-1-dihydrochloride-生命科学试剂-MCE.pdfVIP

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LRH-1antagonist-1dihydrochloride

Cat.No.:HY-128453A

CASNo.:2932459-63-5

分⼦式:C₂₁H₃₀Cl₂N₆

分⼦量:437.41

作⽤靶点:OrphanNuclearReceptor

作⽤通路:VitaminDRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LRH-1antagonist-1(Compound3d2)dihydrochloride是⼀种LRH-1拮抗剂，其Kd为1.8μM。LRH-1

antagonist-1dihydrochloride抑制LRH-1转录活性，降低G0S2表达。LRH-1antagonist-1dihydrochloride

抑制LRH-1阳性癌细胞增殖。LRH-1antagonist-1dihydrochloride可⽤于研究胰腺癌、结肠癌和乳腺癌。

REFERENCES

[1].BenodC,etal.Structure-baseddiscoveryofantagonistsofnuclearreceptorLRH-1.JBiolChem.2013Jul5;288(27):19830-44.

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