LSD1-IN-47-生命科学试剂-MCE.pdfVIP

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Inhibitors•ScreeningLibraries•Proteins

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LSD1-IN-47

Cat.No.:HY-179229

分⼦式:C₄₄H₆₂N₆O₅S

分⼦量:787.07

作⽤靶点:PROTACs;HistoneDemethylase

作⽤通路:PROTAC;Epigenetics

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性LSD1-IN-47是⼀种⾼效的PROTAC降解剂，靶向LSD1(IC50=43nM)。LSD1-IN-47不会改变LSD1蛋⽩⽔平

，也不会增加组蛋⽩标记H3K4me2。LSD1-IN-47可⽤于结肠癌的研究[1]。

体外研究LSD1-IN-47(Compound52)(0.2-20μM,24-72h)doesnotsignificantlyalterLSD1proteinlevelsinHCT116

(humancoloncarcinomacells)cells,anddoesnotincreasethehistonemarkerH3K4me2[1].

WesternBlotAnalysis[1]

CellLine:HCT116cells

Concentration:0.2μM,2μM,20μM

IncubationTime:24h,48h,72h

Result:DidnotinduceLSD1degradationoraffectH3K4me2levels.

REFERENCES

[1].CoulsonME,etal.Syntheticandstructure-activitystudiesofSP2577andTCPtowardsLSD1targetingPROTACs.RSCMedChem.

2025Aug5;1