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RESEARCHARTICLE

DirectQuantitationofSARS-CoV-2VirusinUrbanAmbient

AirviaaContinuous-FlowElectrochemicalBioassay

FuzeJiang,BeiLiu,YangYue,YileTao,ZhenXiao,MengLi,ZhengJi,JiukaiTang,

GuangyuQiu,MartinSpillmann,JunjiCao,LianjunZhang,andJingWang*

1.Introduction

AirborneSARS-CoV-2virussurveillancefaceschallengesincomplicated

biomarkerenrichment,interferencesfromvariousnon-specificmattersandThespreadofCOVID-19isstillthreaten-

extremelylowviralloadintheurbanambientair,leadingtodifficultiesiningglobalpublichealth.Evenincountries

wherehighvaccinationratesareachieved,

detectingSARS-CoV-2bioaerosols.Thisworkreportsahighlyspecificbreakthroughinfectionshavebeenfre-

bioanalysisplatform,withanexceptionallylowlimit-of-detection(≤1quentlyreported.[1]Accumulativeevidence

copym−3)andgoodanalyticalaccordancewithRT-qPCR,relyingonsuggeststhataerosoltransmissioniscriti-

surface-mediatedelectrochemicalsignalingandenzyme-assistedsignalcalforspreadingtheSARS-CoV-2virus.Air-

amplification,enablinggeneandsignalamplificationforaccurateborneSARS-CoV-2particleswithanaero-

dynamicdiameterlessthan10μmcanre-

identificati