R-FTY720-vinylphosphonate-生命科学试剂-MCE.pdfVIP

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(R)-FTY720-vinylphosphonate

Cat.No.:HY-112485

CASNo.:1142015-25-5

分⼦式:C₂₀H₃₄NO₄P

分⼦量:383.46

作⽤靶点:SphK;DrugDerivative

作⽤通路:Immunology/Inflammation;Others

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(R)-FTY720-vinylphosphonate是⼀种鞘氨醇激酶1(SK1)抑制剂。(R)-FTY720-vinylphosphonate也是⼀种

FTY720的类似物。(R)-FTY720-vinylphosphonate有望⽤于乳腺癌等实体肿瘤的研究。

REFERENCES

[1].LimKG,etal.FTY720analoguesassphingosinekinase1inhibitors:enzymeinhibitionkinetics,allosterism,proteasomaldegradation,

andactinrearrangementinMCF-7breastcancercells.JBiolChem.2011May27;286(21):18633-40.

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