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RG-12525(Standard)

Cat.No.:HY-101676R

CASNo.:120128-20-3

分⼦式:C₂₅H₂₁N₅O₂

分⼦量:423.47

作⽤靶点:LeukotrieneReceptor;ReferenceStandards;PPAR;

CytochromeP450

作⽤通路:GPCR/GProtein;Others;CellCycle/DNADamage;Metabolic

Enzyme/Protease;VitaminDRelated/NuclearReceptor

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性RG-12525(Standard)是RG-12525(HY-101676)的分析标准品。本产品⽤于研究及分析应⽤。RG-12525是⼀

种特异性的，竞争性的，可⼝服的LTC4，LTD4和LTE4拮抗剂，能够抑制LTC4，LTD4和LTE4诱导的豚⿏薄

壁带收缩，IC50值分别为2.6nM，2.5nM和7nM；RG-12525也是PPAR-γ的激动剂，IC

IC50TargetIC50:appr60nM(PPAR-γ)[2]

REFERENCES

[1].VanInwegenRG,etal.AntagonismofpeptidoleukotrienesandinhibitionofsystemicanaphylaxisbyRG12525inguineapigs.LifeSci.

1989;44(12):799-807.

[2].FayerJL,etal.LackofcorrelationbetweeninvitroinhibitionofCYP3A-mediatedmetabolismbyaPPAR-gammaagonistanditseffect

ontheclinicalpharmacokineticsofmidazolam