SET-12-生命科学试剂-MCE.pdfVIP

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SET-12

Cat.No.:HY-179710

CASNo.:2241572-39-2

分⼦式:C₂₁H₂₉NO₄

分⼦量:359.46

作⽤靶点:Parasite;ReactiveOxygenSpecies(ROS);DNA/RNA

Synthesis;Apoptosis

作⽤通路:Anti-infection;Immunology/Inflammation;Metabolic

Enzyme/Protease;NF-κB;CellCycle/DNADamage;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性SET-12是⼀种对亚马逊利什曼原⾍具有⾼活性和⾼选择性的抗寄⽣⾍剂。SET-12对亚马逊利什曼原⾍前鞭⽑

体表现出优异的活性，IC₅₀为10.89μM，选择性指数(SI)⾼达12.1。SET-12对细胞内⽆鞭⽑体同样有效，IC

₅₀为3.81μM，选择性指数(SI)进⼀步提升⾄34.5。SET-12造成寄⽣⾍细胞凋亡(apoptosis)的迹象，包括线

粒体损伤和ROS积累。

REFERENCES

[1].Calero-DocinaIM,etal.Leishmanicidalandtrypanocidalpotentialofß,γ-unsaturatedcarboxylicacidsyntheticderivatives.EurJMed

Chem.2026Feb5;303:118390.

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