S-FTY-720-Vinylphosphonate-生命科学试剂-MCE.pdfVIP

Hotline:400-820-3792

Inhibitors•ScreeningLibraries•Proteins

www.MedChemE

(S)-FTY-720Vinylphosphonate

Cat.No.:HY-12898

CASNo.:1142015-13-1

分⼦式:C₂₀H₃₄NO₄P

分⼦量:383.46

作⽤靶点:LPLReceptor;Apoptosis

作⽤通路:GPCR/GProtein;Apoptosis

储存⽅式:Pleasestoretheproductundertherecommendedconditionsin

theCertificateofAnalysis.

BIOLOGICALACTIVITY

⽣物活性(S)-FTY-720Vinylphosphonate是Fingolimod(HY-11063)的⼿性膦酸酯类似物。(S)-FTY-720

Vinylphosphonate能激活S1P1受体，EC50为75nM。(S)-FTY-720Vinylphosphonate可显著抑制

Camptothecin(HY-16560)诱导的IEC-6细胞凋亡(apoptosis)。(S)-FTY-720Vinylphosphonate可⽤于⾃⾝免

疫疾病的研究。

REFERENCES

[1].LuX,SunC,etal.ChiralvinylphosphonateandphosphonateanaloguesoftheimmunosuppressiveagentFTY720.JOrgChem.2009

Apr17;74(8):3192-5.

McePdfHeight

Caution:Producthasnotbeenfullyvalidatedformedicalapplications.

Forresearchuseonly.

Tel:400-820-3792;021Fax:021E-mail:tech@MedChemE

1/1MasterofBioactiveMolecules—